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The deal, which will make Calimmune part of Pennsylvania-based CSL Behring, also includes up to $325 million in potential performance based milestone payments over eight or more years after the transaction鈥檚 close, expected within the next two weeks.

Calimmune, co-founded by UA biology grad and entrepreneur Louis Breton in 2006, is developing stem-cell gene therapy to strengthen patients鈥� own immune systems.

The company鈥檚 technology is based on research by co-founder and Nobel Prize winner David Baltimore of the California Institute of Technology, Irvin Chen of UCLA and Inder M. Verma of the Salk Institute for Biological Studies.

Calimmune鈥檚 clinical and laboratory operations are based in Pasadena, California, and Sydney, Australia, while its corporate office is in Tucson.

In 2013, Calimmune won an $8.3 million grant from the California Institute for Regenerative Medicine to study its HIV drug. Its lead drug candidate is in Phase I/II clinical trials as a one-time treatment to prevent HIV progression to AIDS.

The acquisition will give CSL Behring Calimmune鈥檚 pre-clinical drug candidate, CAL-H, a stem-cell gene therapy for the treatment of sickle cell disease and blood disorders, complementing the company鈥檚 current product portfolio, CSL said.

The deal also includes two proprietary Calimmune technologies to select genetically modified stem cells and to produce viruses used to deliver gene therapy.

CSL Ltd. CEO Paul Perreault said the acquisition will boost his company鈥檚 growth in gene therapy, calling Calimmune鈥檚 accomplishments thus far 鈥渋mpressive.鈥�

鈥淲hile Calimmune is still in the early stages, we believe that our combined strengths have tremendous potential to change treatment paradigms, and most importantly, significantly improve the lives of our patients,鈥� Perreault said in a news release.

Breton, Calimmune鈥檚 CEO, said CSL is an established global leader in protein-replacement therapies, with a track record of driving new treatments to the global marketplace.

鈥淭ogether, we are well positioned to take our achievements to the next level,鈥� Breton said.

In 2015, Calimmune completed a $15 million Series B financing round, led by a large pharmaceutical company.

Members of Tucson鈥檚 Desert Angels investment group also provided early private-equity funding for the company.

CSL is one of the biggest biotech drug companies in the world, with fiscal 2016 revenue of $6.1 billion.

About 40 percent of the company鈥檚 revenues come from immunoglobulin products used to treat immunodeficient patients, while it also markets products such as vaccines and antivenins and operates CSL plasma-collection centers.